Science & Tech

Pathogen Surveillance and Metagenome Sequencing

  • Genome sequencing methods were critical in identifying the agent responsible for the COVID epidemic.
  • This method, known as metagenomics, has transformed pathogen detection and surveillance, allowing for rapid reaction to new threats.

Metagenomics and COVID-19

  • Unprecedented Scale: Scientists used genome sequencing to quickly identify SARS-CoV-2, making it one of the most sequenced creatures in history.
  • Rather than using typical microbiological methods, patient samples were directly exposed to genome sequencing, which accelerated virus detection.
  • Global Genome Surveillance: The success of genome sequencing has resulted in the development of technologies such as the CovidSeq assay, as well as national and worldwide SARS-CoV-2 genome surveillance projects.

Pathogen Surveillance Application

  • Genome Surveillance methods: Several genome sequencing-based methods, like as the CovidSeq assay, have been developed for SARS-CoV-2 detection.
  • GISAID Repository: In response to high-throughput genome surveillance efforts, GISAID established a repository for global genome-sequence data.
  • India’s Initiatives: To support national-level initiatives, India launched a national genome-sequencing and surveillance programme for SARS-CoV-2.

Nigerian Investigation and Metagenomic Sequencing

  • Metagenomics: Nigerian scientists used metagenomic sequencing to evaluate pathogen surveillance in three patient cohorts.
  • The study discovered 13 different viruses among the cohorts, which facilitated in the detection of co-infections and undiagnosed diseases.
  • Diagnostic Potential: In certain cases, metagenomics was able to link symptoms to pesticide poisoning, demonstrating its diagnostic potential.
  • Diverse Applications and Future Prospects: Genome sequencing technologies are being used to detect additional infections such as Zika, dengue fever, lumpy skin disease, and drug-resistant tuberculosis.
  • Environmental Surveillance: Genome surveillance is being expanded to include a variety of sources, including wastewater, air, soil, and animals, to aid in early detection and response tactics.
  • Disease Defence: Genome sequencing is a cornerstone for future disease detection, surveillance, and response due to its speed, precision, and adaptability.
And get notified everytime we publish a new blog post.